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Cell. 2002 Nov 27;111(5):611-3.

The poly(A) tail of mRNAs: bodyguard in eukaryotes, scavenger in bacteria.

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  • 1Ecole Normale SupĂ©rieure, CNRS UMR8541, 46 rue d'Ulm, 75230, Paris, France. mdreyfus@biologie.ens.fr

Abstract

In eukaryotes, poly(A) tails usually act as stabilizers of intact mRNAs, whereas in E. coli they serve to accelerate the destruction of fragments. The mechanisms underlying these contrasting effects of the same RNA modification are discussed.

PMID:
12464173
[PubMed - indexed for MEDLINE]
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