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Nutr Rev. 2002 Nov;60(11):378-87.

Approaches to the reversal of malnutrition, inflammation, and atherosclerosis in end-stage renal disease.

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  • 1Department of Medicine, Division of Nephrology, Gulhane Military Medical School, Ankara, Turkey.


Uremic malnutrition and chronic inflammation are important comorbid conditions that predict poor clinical outcome in end-stage renal disease (ESRD) patients. These conditions are also closely associated with cardiovascular disease, the major cause of death in ESRD patients. A pathophysiologic link between malnutrition, inflammation, and atherosclerosis has been proposed in this patient population. Indeed, multiple lines of evidence suggest that chronic inflammation can predispose ESRD patients to a catabolic and atherogenic state. Malnutrition can also result from chronic inflammation and can accelerate the progression of cardiovascular disease. Whereas a single common etiology has not been identified in this complex process, nutritional and anti-inflammatory interventions provide potential treatment options to counter the high mortality and morbidity in ESRD patients.

[PubMed - indexed for MEDLINE]
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