Nat Rev Immunol. 2002 Dec;2(12):965-75.

A blast from the past: clearance of apoptotic cells regulates immune responses.

Savill J, Dransfield I, Gregory C, Haslett C.

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MRC/University of Edinburgh Centre for Inflammation Research, Department of Clinical & Surgical Sciences (Internal Medicine), Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, UK. J.Savill@ed.ac.uk

Abstract

Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of dying cells by monocytes/macrophages and dendritic cells can also influence immune responses markedly by enhancing or suppressing inflammation. Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future.

PMID:: 12461569; [PubMed - indexed for MEDLINE]

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