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Nat Rev Mol Cell Biol. 2002 Dec;3(12):919-31.

Sorting out the cellular functions of sorting nexins.

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  • 1Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

Erratum in

  • Nat Rev Mol Cell Biol. 2003 Feb;4(2):156..


Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif - the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein-protein complexes, points to a role for these proteins in membrane trafficking and protein sorting. It will be interesting to determine whether the various sorting nexins have specialized or generalized roles in protein trafficking.

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