Format

Send to:

Choose Destination
See comment in PubMed Commons below
Bull Exp Biol Med. 2002 Aug;134(2):175-6.

Relative content of cytokines in different tissues in mycosis fungoides.

Author information

  • 1Central Institute of Dermatology and Venereology, Ministry of Health of the Russian Federation, Moscow. msavv@hotmail.com

Abstract

The concentrations of tumor necrosis factor-alpha, interleukin-1beta, interleukin-2, interleukin-4, and the content of antibodies to H1 histone fraction in peripheral blood lymphocytes, epidermis, and serum were evaluated in patients with mycosis fungoides. It was found that as the disease progresses, cytokine synthesis is switched from Th1 to Th2 class and production of proinflammatory cytokines increases, which indirectly promotes the development of the autoimmune reaction.

PMID:
12459845
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk