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Nat Rev Cancer. 2002 Dec;2(12):910-7.

The retinoblastoma tumour suppressor in development and cancer.

Author information

  • 1MGH Cancer Center, Building 149, 13th Street, Room 7330, Charlestown, Massachusetts 02129, USA. classon@helix.mgh.harvard.edu

Abstract

Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal point of cancer research. Accumulating evidence indicates a complex role for RB in cell proliferation, differentiation and survival. To further complicate matters, proteins that are related to RB have redundant as well as antagonistic functions. Recent studies of knockout mice and cells that lack one or more of these proteins have begun to clarify their various context-specific functions and the unique activity of this tumour suppressor.

PMID:
12459729
[PubMed - indexed for MEDLINE]
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