Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neurosci Lett. 2002 Dec 25;335(2):95-8.

The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat.

Author information

  • 1Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53223, USA.

Abstract

Several recent studies have demonstrated a neuromodulatory role for endocannabinoids via their ability to act as retrograde inhibitors of synaptic neurotransmission. We utilized the functional hyperemic response to controlled whisker stimulation to determine whether endogenous cannabinoids modulate synaptic transmission within the primary somatosensory cortex of rats. As previously demonstrated, whisker-stimulation resulted in a robust hyperemic response measured using laser Doppler flowmetry within the whisker barrel cortex. Administration of the CB(1) receptor antagonist, SR141716 (1 mg/kg i.v.), significantly potentiated the functional hyperemic response to whisker-stimulation, while having no effect on basal blood flow within the whisker barrel cortex. These data suggest that suppression of endogenous cannabinergic neurotransmission results in increased cortical activity in response to physiological sensory stimulation.

PMID:
12459507
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk