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Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16203-8. Epub 2002 Nov 27.

Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis.

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  • 1Departments of Pathology and Surgery, University of Hong Kong, Hong Kong, China.

Abstract

We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately equal 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.

PMID:
12456890
[PubMed - indexed for MEDLINE]
PMCID:
PMC138589
Free PMC Article

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