Mol Cell. 2002 Nov;10(5):1247-53.

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.

Harris RS, Petersen-Mahrt SK, Neuberger MS.

Source

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom. rsharris@mrc-lmb.cam.ac.uk

Abstract

APOBEC1 is the catalytic component of an RNA editing complex but shows homology to activation-induced cytidine deaminase (AID), a protein whose function is to potentiate diversification of immunoglobulin gene DNA. Here, we show that APOBEC1 and its homologs APOBEC3C and APOBEC3G exhibit potent DNA mutator activity in an E. coli assay. Indeed, like AID, these proteins appear to trigger DNA mutation through dC deamination. However, each protein exhibits a distinct local target sequence specificity. The results reveal the existence of a family of potential active dC/dG mutators, with possible implications for cancer.

PMID:: 12453430; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases. [Mol Biol Evol. 2005]
Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.
Conticello SG, Thomas CJ, Petersen-Mahrt SK, Neuberger MS. Mol Biol Evol. 2005 Feb; 22(2):367-77. Epub 2004 Oct 20.
Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo. [J Mol Biol. 2004]
Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo.
Beale RC, Petersen-Mahrt SK, Watt IN, Harris RS, Rada C, Neuberger MS. J Mol Biol. 2004 Mar 26; 337(3):585-96.
In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1). [J Biol Chem. 2003]
In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1).
Petersen-Mahrt SK, Neuberger MS. J Biol Chem. 2003 May 30; 278(22):19583-6. Epub 2003 Apr 14.
Review A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes. [DNA Repair (Amst). 2003]
Review A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes.
Diaz M, Storb U. DNA Repair (Amst). 2003 May 13; 2(5):623-7.
Review The AID/APOBEC family of nucleic acid mutators. [Genome Biol. 2008]
Review The AID/APOBEC family of nucleic acid mutators.
Conticello SG. Genome Biol. 2008; 9(6):229. Epub 2008 Jun 17.

See reviews... See all...

Cited by 78 PubMed Central articles

APOBEC1-mediated editing and attenuation of herpes simplex virus 1 DNA indicate that neurons have an antiviral role during herpes simplex encephalitis. [J Virol. 2011]
APOBEC1-mediated editing and attenuation of herpes simplex virus 1 DNA indicate that neurons have an antiviral role during herpes simplex encephalitis.
Gee P, Ando Y, Kitayama H, Yamamoto SP, Kanemura Y, Ebina H, Kawaguchi Y, Koyanagi Y. J Virol. 2011 Oct; 85(19):9726-36. Epub 2011 Jul 20.
Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons. [Nucleic Acids Res. 2011]
Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons.
Ikeda T, Abd El Galil KH, Tokunaga K, Maeda K, Sata T, Sakaguchi N, Heidmann T, Koito A. Nucleic Acids Res. 2011 Jul; 39(13):5538-54. Epub 2011 Mar 12.
Association of potent human antiviral cytidine deaminases with 7SL RNA and viral RNP in HIV-1 virions. [J Virol. 2010]
Association of potent human antiviral cytidine deaminases with 7SL RNA and viral RNP in HIV-1 virions.
Zhang W, Du J, Yu K, Wang T, Yong X, Yu XF. J Virol. 2010 Dec; 84(24):12903-13. Epub 2010 Oct 6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioAssay
PubChem BioAssay experiments on the biological activities of small molecules that cite the current articles. The depositors of BioAssay data provide these references.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.
Mol Cell. 2002 Nov ;10(5):1247-53.

PubMed
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins i...
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
Mol Cell. 2002 Nov ;10(5):1119-28.

PubMed
REDD1, a developmentally regulated transcriptional target of p63 and p53, links ...
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species.
Mol Cell. 2002 Nov ;10(5):995-1005.

PubMed
Seasonal correlation of sporadic schizophrenia to Ixodes ticks and Lyme borrelio...
Seasonal correlation of sporadic schizophrenia to Ixodes ticks and Lyme borreliosis.
Int J Health Geogr. 2002 Nov 1;1(1):2.

PubMed
Hormone-dependent fluctuations of pressure pain threshold and tactile threshold ...
Hormone-dependent fluctuations of pressure pain threshold and tactile threshold of the temporalis and masseter muscle.
J Oral Rehabil. 2002 Nov ;29(11):1042-51.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 78 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information