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Neuron. 2002 Nov 14;36(4):549-50.

Spatially restricted actions of BDNF.

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  • Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95616, USA.


In this issue of Neuron, Zhang and Poo present evidence for localized BDNF-induced synaptic potentiation that is accompanied by spatially restricted calcium influx and requires local axonal protein synthesis. These results are consistent with a synapse-specific role for BDNF and provide a potentially novel way to think about cellular mechanisms for potentiation of neurotransmitter release.

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