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Am J Obstet Gynecol. 2002 Nov;187(5):1389-94.

Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial.

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  • 1Department of Clinical Epidemiology and Biostatistics, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands.

Abstract

OBJECTIVE:

The purpose of this study was to evaluate the effect of evening primrose oil and fish oil on breast pain in premenopausal women with severe chronic mastalgia, in a randomized double-blind factorial clinical trial.

STUDY DESIGN:

One hundred twenty women were placed randomly into four groups: (1) fish oil and control oil, (2) evening primrose oil and control oil, (3) fish and evening primrose oils, or (4) both control oils during 6 months. Corn oil and corn oil with wheat germ oil were used as control oils. The change in the percentage of days with breast pain after 6 months of treatment was analyzed on an intention-to-treat basis.

RESULTS:

The decrease in days with pain was 12.3 % for evening primrose oil and 13.8% for its control oil (P =.73); the decrease in days with pain was 15.5% for fish oil and 10.6% for its control oil (P =.28).

CONCLUSION:

All groups showed a decrease in pain. Neither evening primrose oil nor fish oil offered clear benefit over control oils in the treatment of mastalgia.

PMID:
12439536
[PubMed - indexed for MEDLINE]
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