The role of dipeptidyl peptidase IV (DP IV) enzyma...[Biol Chem. 2002 Jul-Aug]

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1: Biol Chem. 2002 Jul-Aug;383(7-8):1133-8. Links

The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity.

Reinhold D, Kähne T, Steinbrecher A, Wrenger S, Neubert K, Ansorge S, Brocke S.

Institute of Immunology, Otto-von-Gueircke University Magdeburg, Germany.

Activated T lymphocytes express high levels of dipeptidyl peptidase IV (DP IV)/CD26. Recent studies support the notion that DP IV may play an important role in the regulation of differentiation and growth of T lymphocytes. This article gives a short overview on DP IV/CD26 expression and effects on immune cells in vitro and in vivo. A major focus of this review are clinical aspects of the function of CD26 on hematopoietic cells and the potential usage of synthetic DP IV inhibitors as therapeutics in inflammatory disorders.

PMID: 12437097 [PubMed - indexed for MEDLINE]

Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones.
J Neuroimmunol. 1998 Jul 1; 87(1-2):203-9.

[J Neuroimmunol. 1998]
Alterations in structure and cellular localization of molecular forms of DP IV/CD26 during T cell activation.
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[Cell Immunol. 1996]
ReviewDipeptidyl peptidase IV: a cell surface peptidase involved in regulating T cell growth (review).
Int J Mol Med. 1999 Jul; 4(1):3-15.

[Int J Mol Med. 1999]
Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo.
J Immunol. 2001 Feb 1; 166(3):2041-8.

[J Immunol. 2001]
ReviewDual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses.
Ann N Y Acad Sci. 2007 Sep; 1110:402-9.

[Ann N Y Acad Sci. 2007]
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