Osteoporosis and the growth hormone-insulin-like growth factor axis

Horm Res. 2002:58 Suppl 3:49-55. doi: 10.1159/000066483.

Abstract

Osteoporosis is the result of an imbalance between bone resorption and bone formation. Currently, mainly drugs that inhibit bone resorption are available for the treatment of osteoporosis. A new approach in the treatment of osteoporosis is the use of anabolic agents that increase bone turnover, both bone formation and resorption. Growth hormone (GH) and insulin-like growth factors (IGFs) are essential in the development and growth of the skeleton and for the maintenance of bone mass and density. We will review the evidence of GH and IGF-I in the pathophysiology and treatment of osteoporosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Aging / physiology
  • Animals
  • Bone Diseases / etiology
  • Child
  • Growth Hormone / adverse effects
  • Growth Hormone / therapeutic use
  • Human Growth Hormone / deficiency
  • Human Growth Hormone / physiology*
  • Humans
  • Insulin-Like Growth Factor I / adverse effects
  • Insulin-Like Growth Factor I / therapeutic use
  • Osteoporosis / drug therapy
  • Osteoporosis / physiopathology*
  • Somatomedins / physiology*

Substances

  • Somatomedins
  • Human Growth Hormone
  • Insulin-Like Growth Factor I
  • Growth Hormone