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1: Science. 2003 Jan 3;299(5603):114-6. Epub 2002 Nov 14.Click here to read Click here to read Links

Regulation of chromatin remodeling by inositol polyphosphates.

Steger DJ, Haswell ES, Miller AL, Wente SR, O'Shea EK.

Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0448, USA.

Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5 gene, we identified mutations in ARG82/IPK2, which encodes a nuclear inositol polyphosphate kinase. In arg82 mutant strains, remodeling of PHO5 promoter chromatin is impaired, and the adenosine triphosphate-dependent chromatin-remodeling complexes SWI/SNF and INO80 are not efficiently recruited to phosphate-responsive promoters. These results suggest a role for the small molecule inositol polyphosphate in the regulation of chromatin remodeling and transcription.

PMID: 12434012 [PubMed - indexed for MEDLINE]

PMCID: PMC1458531