Int J Pharm. 2002 Dec 5;249(1-2):1-5.

Oral absorption of insulin encapsulated in artificial chyles of bile salts, palmitic acid and alpha-tocopherol dispersions.

Source

Division of Pharmaceutics and Industrial Pharmacy, Arnold and Marie Schwartz College of Pharmacy, Long Island University, 75 DeKalb Avenue, Brooklyn, NY 11201, USA. mmesiha@liu.edu

Abstract

The hypoglycemic effect of orally given insulin was studied on rabbits, using different bile salts as absorption promoters, in two different carriers to form an artificial chyloform system ready to be absorbed by intestinal mucosa. The rank order of enhancement by bile salts in the presence of 1% ethanol was deoxycholate>cholate>glycocholate>glycodeoxycholate>taurodeoxycholate>no bile salts. The dose response studies with increased insulin loaded in the chyle showed a greater corresponding hypoglycemic effect with the system of cholate-palmitic-alpha-tocopherol dispersions than the cholate-palmitic acid dispersions. A more effective hypoglycemic effect was achieved using lower doses of the deoxycholate-palmitate-tocopherol-chyle dispersions.

PMID:: 12433429; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Diabetes Medicines - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Promotion of oral insulin absorption in diabetic rabbits using pH-dependent coated capsules containing sodium cholate. [Pharm Acta Helv. 1997]
Promotion of oral insulin absorption in diabetic rabbits using pH-dependent coated capsules containing sodium cholate.
Hosny EA, Ghilzai NM, Elmazar MM. Pharm Acta Helv. 1997 Sep; 72(4):203-7.
Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon. [J Pharm Sci. 1997]
Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon.
Tozaki H, Komoike J, Tada C, Maruyama T, Terabe A, Suzuki T, Yamamoto A, Muranishi S. J Pharm Sci. 1997 Sep; 86(9):1016-21.
Effect of different bile salts on the relative hypoglycemia of witepsol W35 suppositories containing insulin in diabetic Beagle dogs. [Drug Dev Ind Pharm. 2001]
Effect of different bile salts on the relative hypoglycemia of witepsol W35 suppositories containing insulin in diabetic Beagle dogs.
Hosny EA, Al-Shora HI, Elmazar MM. Drug Dev Ind Pharm. 2001 Sep; 27(8):837-45.
Review Developments in polymeric devices for oral insulin delivery. [Expert Opin Drug Deliv. 2008]
Review Developments in polymeric devices for oral insulin delivery.
Babu VR, Patel P, Mundargi RC, Rangaswamy V, Aminabhavi TM. Expert Opin Drug Deliv. 2008 Apr; 5(4):403-15.
Review Nanoparticle strategies for the oral delivery of insulin. [Expert Opin Drug Deliv. 2008]
Review Nanoparticle strategies for the oral delivery of insulin.
Damgé C, Reis CP, Maincent P. Expert Opin Drug Deliv. 2008 Jan; 5(1):45-68.

See reviews... See all...

Cited by 1 PubMed Central article

L-tyrosine-loaded nanoparticles increase the antitumoral activity of direct electric current in a metastatic melanoma cell model. [Int J Nanomedicine. 2010]
L-tyrosine-loaded nanoparticles increase the antitumoral activity of direct electric current in a metastatic melanoma cell model.
de Campos VE, Teixeira CA, da Veiga VF, Ricci E Jr, Holandino C. Int J Nanomedicine. 2010 Nov 15; 5:961-71. Epub 2010 Nov 15.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Oral absorption of insulin encapsulated in artificial chyles of bile salts, palm...
Oral absorption of insulin encapsulated in artificial chyles of bile salts, palmitic acid and alpha-tocopherol dispersions.
Int J Pharm. 2002 Dec 5 ;249(1-2):1-5.

PubMed
Interleukin-1beta increases urine flow rate and inhibits protein expression of N...
Interleukin-1beta increases urine flow rate and inhibits protein expression of Na(+)/K(+)-ATPase in the rat jejunum and kidney.
J Interferon Cytokine Res. 2002 Oct ;22(10):1041-8.

PubMed
Epigenomics: genome-wide study of methylation phenomena.
Epigenomics: genome-wide study of methylation phenomena.
Curr Issues Mol Biol. 2002 Oct ;4(4):111-28.

PubMed
Allene oxide synthases and allene oxides.
Allene oxide synthases and allene oxides.
Prostaglandins Other Lipid Mediat. 2002 Aug ;68-69:423-31.

PubMed
The structures of prostaglandin endoperoxide H synthases-1 and -2.
The structures of prostaglandin endoperoxide H synthases-1 and -2.
Prostaglandins Other Lipid Mediat. 2002 Aug ;68-69:129-52.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Oral absorption of insulin encapsulated in artificial chyles of bile salts, palmitic acid and alpha-tocopherol dispersions.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information