Arch Pharm Res. 2002 Oct;25(5):636-9.

The radical scavenging effects of stilbene glucosides from Polygonum multiflorum.

Ryu G, Ju JH, Park YJ, Ryu SY, Choi BW, Lee BH.

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Regional Research Center and Department of Chemical Technology, Hanbat National University, Yusung-ku, Daejon, Korea.

Abstract

The extract of the root of Polygonum multiflorum exhibited a significant antioxidant activity assessed by the DPPH radical scavenging activity in vitro. The bioassay-guided fractionation of the extract yielded a stilbene glucoside, (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucopyranoside (1) as an active constituent responsible for the antioxidant property. Compound 1 demonstrated a moderate DPPH radical scavenging activity (IC50, 40 microM), while the corresponding deglucosylated stilbene 2 exhibited a much higher activity (IC50, 0.38 microM).

PMID:: 12433196; [PubMed - indexed for MEDLINE]

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The radical scavenging effects of stilbene glucosides from Polygonum multiflorum.

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