Neuropsychopharmacology. 2002 Nov;27(5):869-73.

Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor.

Source

W. M. Keck Foundation Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, CA 94143, USA. mgf@phy.ucsf.edu

Abstract

Studies in humans and rats indicate that serotonin (5-hydroxytryptamine, 5-HT) receptors are involved in mammalian sleep expression. We investigated the contribution of the 5-HT2c receptor to sleep expression by examining sleep patterns in mice bearing a targeted null mutation of this receptor. 5-HT2c receptor knock-out mice had more wakefulness, several abnormalities in rapid eye movement sleep expression and an enhanced response to sleep deprivation compared with wild-type control mice. These findings suggest that 5HT2c receptors may mediate several effects on sleep that have been ascribed to serotonin.

PMID:: 12431861; [PubMed - indexed for MEDLINE]
PMCID:: PMC2452994

Free PMC Article

Images from this publication.See all images (3) Free text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Miscellaneous

Mouse Genome Informatics (MGI)

Supplemental Content

Save items

Related citations in PubMed

Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors. [J Neurosci. 2005]
Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors.
Popa D, Léna C, Fabre V, Prenat C, Gingrich J, Escourrou P, Hamon M, Adrien J. J Neurosci. 2005 Dec 7; 25(49):11231-8.
Review [Implication of serotonin in the control of vigilance states as revealed by knockout-mouse studies]. [J Soc Biol. 2004]
Review [Implication of serotonin in the control of vigilance states as revealed by knockout-mouse studies].
Adrien J. J Soc Biol. 2004; 198(1):30-6.
Involvement of 5-HT1A receptors in homeostatic and stress-induced adaptive regulations of paradoxical sleep: studies in 5-HT1A knock-out mice. [J Neurosci. 2002]
Involvement of 5-HT1A receptors in homeostatic and stress-induced adaptive regulations of paradoxical sleep: studies in 5-HT1A knock-out mice.
Boutrel B, Monaca C, Hen R, Hamon M, Adrien J. J Neurosci. 2002 Jun 1; 22(11):4686-92.
Control and function of the homeostatic sleep response by adenosine A1 receptors. [J Neurosci. 2009]
Control and function of the homeostatic sleep response by adenosine A1 receptors.
Bjorness TE, Kelly CL, Gao T, Poffenberger V, Greene RW. J Neurosci. 2009 Feb 4; 29(5):1267-76.
Review The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep. [Sleep Med Rev. 2010]
Review The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep.
Monti JM. Sleep Med Rev. 2010 Oct; 14(5):319-27. Epub 2010 Feb 12.

See reviews... See all...

Cited by 6 PubMed Central articles

Review Genetic analysis of sleep. [Genes Dev. 2010]
Review Genetic analysis of sleep.
Crocker A, Sehgal A. Genes Dev. 2010 Jun 15; 24(12):1220-35.
Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo. [Proc Natl Acad Sci U S A. 2009]
Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo.
Fellin T, Halassa MM, Terunuma M, Succol F, Takano H, Frank M, Moss SJ, Haydon PG. Proc Natl Acad Sci U S A. 2009 Sep 1; 106(35):15037-42. Epub 2009 Aug 17.
Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. [Neuron. 2009]
Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss.
Halassa MM, Florian C, Fellin T, Munoz JR, Lee SY, Abel T, Haydon PG, Frank MG. Neuron. 2009 Jan 29; 61(2):213-9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor.
Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor.
Neuropsychopharmacology. 2002 Nov ;27(5):869-73.

PubMed
Update on biological actions of 1alpha,25(OH)2-vitamin D3 (rapid effects) and 24...
Update on biological actions of 1alpha,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3.
Mol Cell Endocrinol. 2002 Nov 29 ;197(1-2):1-13.

PubMed
Early childhood psychosis and bleeding during pregnancy. A prospective study of ...
Early childhood psychosis and bleeding during pregnancy. A prospective study of gravid women and their offspring.
J Autism Child Schizophr. 1975 Dec ;5(4):287-97.

PubMed
Adjuvant chemotherapy for deep muscle-invasive transitional cell bladder carcino...
Adjuvant chemotherapy for deep muscle-invasive transitional cell bladder carcinoma - a practice guideline.
Can J Urol. 2002 Oct ;9(5):1625-33.

PubMed
Strong binding in the DNA minor groove by an aromatic diamidine with a shape tha...
Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove.
J Am Chem Soc. 2002 Nov 20 ;124(46):13680-1.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Miscellaneous

Supplemental Content

Save items

Related citations in PubMed

Cited by 6 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information