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1: Genome Biol. 2002 Oct 23;3(11):reviews0008. Epub 2002 Oct 23.Click here to read Click here to read Links

Finding signals that regulate alternative splicing in the post-genomic era.

Ladd AN, Cooper TA.

Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA. tcooper@bcm.tmc.edu

Alternative splicing of pre-mRNAs is central to the generation of diversity from the relatively small number of genes in metazoan genomes. Auxiliary cis elements and trans-acting factors are required for the recognition of constitutive and alternatively spliced exons and their inclusion in pre-mRNA. Here, we discuss the regulatory elements that direct alternative splicing and how genome-wide analyses can aid in their identification.

PMID: 12429065 [PubMed - indexed for MEDLINE]

PMCID: PMC244920