[beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers]

Nihon Kokyuki Gakkai Zasshi. 2002 Aug;40(8):637-43.
[Article in Japanese]

Abstract

This study was designed to evaluate, in healthy volunteers, differences of bronchodilator responsiveness to a beta 2-agonist between those with the Arg 16/Gly 16 allele and those with the Gly 16/Gly 16 allele at codon 16 of beta 2 adrenoceptor polymorphism. Peak flow and pulmonary functions were measured by body plethysmography after the inhalation of procaterol. In the Arg 16/Gly 16 group, the resulting acute increase of V 25 and acute decrease of airway resistance were greater, and the bronchodilator effect of a single inhaled beta 2-agonist was longer, than those observed in the Gly 16/Gly 16 group. The present study showed that a single inhalation of procaterol has a varying bronchodilator effect on healthy adults, depending on the genotype of beta 2 adrenoceptor polymorphism at codon 16.

Publication types

  • English Abstract

MeSH terms

  • Administration, Inhalation
  • Adrenergic beta-Agonists / administration & dosage
  • Adrenergic beta-Agonists / pharmacology*
  • Adult
  • Airway Resistance / drug effects*
  • Bronchodilator Agents / administration & dosage
  • Bronchodilator Agents / pharmacology*
  • Female
  • Humans
  • Lung / physiology*
  • Male
  • Plethysmography, Whole Body
  • Polymorphism, Genetic
  • Procaterol / administration & dosage
  • Procaterol / pharmacology*
  • Receptors, Adrenergic, beta-2 / genetics*

Substances

  • Adrenergic beta-Agonists
  • Bronchodilator Agents
  • Receptors, Adrenergic, beta-2
  • Procaterol