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    Annu Rev Immunol. 2003;21:231-64. Epub 2001 Dec 19.

    BAFF AND APRIL: a tutorial on B cell survival.

    Source

    Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, Australia. f.mackay@garvan.unsw.edu.au

    Abstract

    BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature B cells. BAFF overexpression leads to an expanded B cell compartment and autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears to play a different biological role. The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.

    PMID:
    12427767
    [PubMed - indexed for MEDLINE]

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