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Annu Rev Immunol. 2003;21:231-64. Epub 2001 Dec 19.

BAFF AND APRIL: a tutorial on B cell survival.

Author information

  • 1Garvan Institute of Medical Research, Department of Arthritis and Inflammation, Darlinghurst, Australia. f.mackay@garvan.unsw.edu.au

Abstract

BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature B cells. BAFF overexpression leads to an expanded B cell compartment and autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears to play a different biological role. The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.

PMID:
12427767
[PubMed - indexed for MEDLINE]
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