J Hematother Stem Cell Res. 2002 Oct;11(5):765-75.

Stem cell transplantation and gene therapy for HIV-related lymphomas.

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Division of Hematology and Bone Marrow Transplantation, and Department of Virology, City of Hope National Medical Center, Duarte, CA 91010, USA. akrishnan@coh.org

Abstract

The treatment of patients with HIV-related non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD) is less successful than in the non-HIV setting, in part due to the aggressive character of these lymphomas but also due to the underlying HIV infection. High-dose therapy with stem cell transplantation has been used with success in the HIV-negative lymphoma setting for high-risk or relapsed disease. However, for patients with HIV-NHL and HIV-HD, ultimately the chance for long-term lymphoma-free survival also depends on successful control of the HIV infection. Gene therapy approaches may provide the opportunity for this long-term control. Herein, we describe the use of high-dose chemotherapy with stem cell rescue in conjunction with current and future gene therapy approaches for the treatment of HIV-associated lymphomas.

PMID:: 12427283; [PubMed - indexed for MEDLINE]

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Stem cell transplantation and gene therapy for HIV-related lymphomas.

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