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Org Lett. 2002 Nov 14;4(23):4013-6.

Continuous solid-phase synthesis and disulfide cyclization of peptide-PNA-peptide chimeras.

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  • 1Departments of Biochemistry & Molecular Pharmacology and Microbiology & Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Abstract

Chelator peptides were extended from the N-terminus of peptide nucleic acid (PNA) dodecamers, which in turn were extended from the N-termini of disulfide-bridged peptide ligand analogues, using Fmoc coupling for all residues. The cysteine thiols were cyclized on a solid support, either before or after PNA extension. This simplified synthetic approach might allow preparation of a variety of multipeptide disulfide-bridged PNA chimeras. [structure: see text]

PMID:
12423074
[PubMed - indexed for MEDLINE]
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