Trends Mol Med. 2002 Nov;8(11):537-42.

Genetically-modified-animal models for human infections: the Listeria paradigm.

Source

Dept of Molecular Biology and Pharmacology, Washington University School of Medicine Campus Box 8103, 660 So. Euclid Ave, St Louis, MO 63110, USA. mlecuit@passteur.fr

Abstract

Several human pathogens exhibit a restricted host-tropism, relying on the species-specific interaction of microbial ligand(s) with host receptor(s). This specificity accounts for some of the difficulties in modeling human infections in animals. The discovery of L. monocytogenes host-specificity and elucidation of the underlying mechanism has led to the generation of transgenic mice expressing one of its human receptors, E-cadherin. This model is presented here as a paradigm of a genetically-modified-animal model for studying a human infectious disease.

PMID:: 12421688; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Altering tissue tropism of Listeria monocytogenes by ectopically expressing human E-cadherin in transgenic mice. [Microb Pathog. 2003]
Altering tissue tropism of Listeria monocytogenes by ectopically expressing human E-cadherin in transgenic mice.
Luo Y, Lee A, Shen H, Radice GL. Microb Pathog. 2003 Aug; 35(2):57-62.
Modeling human listeriosis in natural and genetically engineered animals. [Nat Protoc. 2009]
Modeling human listeriosis in natural and genetically engineered animals.
Disson O, Nikitas G, Grayo S, Dussurget O, Cossart P, Lecuit M. Nat Protoc. 2009; 4(6):799-810.
A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier. [Science. 2001]
A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier.
Lecuit M, Vandormael-Pournin S, Lefort J, Huerre M, Gounon P, Dupuy C, Babinet C, Cossart P. Science. 2001 Jun 1; 292(5522):1722-5.
Review Listeria monocytogenes: a model system to study invasion and spread of bacteria in the central nervous system. [Curr Top Microbiol Immunol. 2002]
Review Listeria monocytogenes: a model system to study invasion and spread of bacteria in the central nervous system.
Domann E, Deckert M, Schlüter D, Chakraborty T. Curr Top Microbiol Immunol. 2002; 265:213-26.
Review Understanding how Listeria monocytogenes targets and crosses host barriers. [Clin Microbiol Infect. 2005]
Review Understanding how Listeria monocytogenes targets and crosses host barriers.
Lecuit M. Clin Microbiol Infect. 2005 Jun; 11(6):430-6.

See reviews... See all...

Cited by 10 PubMed Central articles

Murinization of Internalin Extends Its Receptor Repertoire, Altering Listeria monocytogenes Cell Tropism and Host Responses. [PLoS Pathog. 2013]
Murinization of Internalin Extends Its Receptor Repertoire, Altering Listeria monocytogenes Cell Tropism and Host Responses.
Tsai YH, Disson O, Bierne H, Lecuit M. PLoS Pathog. 2013 May; 9(5):e1003381. Epub 2013 May 30.
The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}. [Proc Natl Acad Sci U S A. 2010]
The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}.
Gouin E, Adib-Conquy M, Balestrino D, Nahori MA, Villiers V, Colland F, Dramsi S, Dussurget O, Cossart P. Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40):17333-8. Epub 2010 Sep 20.
Characteristics of the phagocytic cup induced by uropathogenic Escherichia coli. [J Histochem Cytochem. 2008]
Characteristics of the phagocytic cup induced by uropathogenic Escherichia coli.
Wang H, Liang FX, Kong XP. J Histochem Cytochem. 2008 Jun; 56(6):597-604. Epub 2008 Mar 17.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Genetically-modified-animal models for human infections: the Listeria paradigm.
Genetically-modified-animal models for human infections: the Listeria paradigm.
Trends Mol Med. 2002 Nov ;8(11):537-42.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: