Brain Res. 2002 Nov 15;955(1-2):264-7.

5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus.

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Department of Psychology, Princeton University, Princeton, NJ 08544, USA. jason.radley@mssm.edu

Abstract

This study investigated the action of 5-HT(1A) receptor antagonists on cell proliferation in the dentate gyrus of adult rats. Three antagonists (NAN-190, p-MPPI and WAY-100635) all produced a statistically significant approximately 30% reduction in the number of BrdU-immunoreactive cells in the dentate gyrus. This suggests that 5-HT(1A) receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation.

PMID:: 12419546; [PubMed - indexed for MEDLINE]

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