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J Biol Chem. 2003 Jan 17;278(3):1910-4. Epub 2002 Nov 3.

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.

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  • 1Department of Molecular Biology, Genentech, South San Francisco, California 94080, USA.

Abstract

Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells. Despite increasing evidence that high levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis, the regulation of its expression is not well characterized. We observe that IL-17 production is increased in response to the recently described cytokine IL-23. We present evidence that murine IL-23, which is produced by activated dendritic cells, acts on memory T cells, resulting in elevated IL-17 secretion. IL-23 also induced expression of the related cytokine IL-17F. IL-23 is a heterodimeric cytokine and shares a subunit, p40, with IL-12. In contrast to IL-23, IL-12 had only marginal effects on IL-17 production. These data suggest that during a secondary immune response, IL-23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles.

PMID:
12417590
[PubMed - indexed for MEDLINE]
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