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Telomerase: biochemical considerations for enzyme and substrate.
Swiss Institute for Experimental Cancer Research (ISREC), CH-1066 Epalinges, Switzerland.
Telomerase extends chromosome ends by iterative reverse transcription of its RNA template. Following the addition of each telomeric repeat, the RNA template and the telomeric substrate reset their relative position in the active site provided by the telomerase reverse transcriptase (TERT). This step might require the formation of guanine-rich secondary structures in the nascent product. Results from numerous studies begin to delineate TERT sub-domains that orchestrate these events and support the model of cooperative action between distinct active sites within telomerase multimers. Natural telomere substrates are protein-DNA complexes that show an asymmetry between the two ends of a chromosome, possibly reflecting their differential mode of replication.
PMID: 12417133 [PubMed - indexed for MEDLINE]
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Cited by 36 PubMed Central articles
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A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.
Imamura S, Uchiyama J, Koshimizu E, Hanai J, Raftopoulou C, Murphey RD, Bayliss PE, Imai Y, Burns CE, Masutomi K, et al.
PLoS One. 2008; 3(10):e3364. Epub 2008 Oct 10.
[PLoS One. 2008]
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TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres.
Gallardo F, Olivier C, Dandjinou AT, Wellinger RJ, Chartrand P.
EMBO J. 2008 Mar 5; 27(5):748-57. Epub 2008 Feb 14.
[EMBO J. 2008]
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Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast.
Subramanian L, Moser BA, Nakamura TM.
Mol Cell Biol. 2008 Mar; 28(5):1443-55. Epub 2007 Dec 26.
[Mol Cell Biol. 2008]
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