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1: Rev Invest Clin. 2002 Jul-Aug;54(4):342-8.Links

[Telomerase: an enzyme with multiple applications in cancer research]

[Article in Spanish]

Castillo Ureta H, Barrera Saldaña HA, Martínez Rodríguez HG.

Laboratorio de Biología Celular, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.

The telomerase is a ribonucleoprotein enzyme to which multiple functions have been attributed, the most important of these is the maintenance of the telomere which is related with cellular immortalization and cancer. 85% of human tumors have telomerase activity, that in normal cells goes undetected. These characteristics make the telomerase an attractive target for chemotherapy.

PMID: 12415959 [PubMed - indexed for MEDLINE]