Eur J Clin Microbiol Infect Dis. 2002 Oct;21(10):755-7. Epub 2002 Oct 3.

Oro-dental bacteria in various atherosclerotic arteries.

Taylor-Robinson D, Aduse-Opoku J, Sayed P, Slaney JM, Thomas BJ, Curtis MA.

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Imperial College School of Medicine, St. Mary's Campus, Winston Churchill Wing, Paddington, London W2 1NY, United Kingdom, dtr@vache99.freeserve.co.uk

Abstract

Chlamydia pneumoniae DNA has been detected in at least 40% of all major arteries affected by atherosclerosis, but several other microorganisms have also been detected. In this study, diseased vessels were evaluated for the presence of the DNA of seven oro-dental bacteria and two nonoral bacteria. A polymerase chain reaction technique was employed using primer pairs based on 16S rRNA genes. Of 32 specimens tested, 10 (31.2%) were DNA positive: seven for Actinobacillus actinomycetemcomitans and three for Prevotella intermedia. The DNA was found in specimens from the aorta and the iliac, internal mammary and coronary arteries. Eleven (35.4%) of 31 specimens had been shown previously to be positive for Chlamydia pneumoniae DNA. A mixture of chlamydiae and oro-dental bacteria was found in three cases. These findings may have implications for antibiotic prophylaxis of coronary heart disease if directed solely at Chlamydia pneumoniae.

PMID:: 12415477; [PubMed - indexed for MEDLINE]

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