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Curr Opin Chem Biol. 2002 Oct;6(5):666-75.

Analytical aspects of mass spectrometry and proteomics.

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  • 1Barnett Institute and Department of Chemistry, Northeastern University, 341 Mugar Hall, 360 Huntington Avenue, Boston, Massachusetts 02115, USA.


Mass spectrometry plays an essential role in proteomics analysis and research. In recent years, it has been increasingly recognized that a key to proteomics using mass spectrometry relies not only on the instrument itself, but also on the analytical strategies and front-end sample-handling techniques. The advances of separations and mass spectrometry are having an increasing impact on the discovery of disease biomarkers and the understanding of cellular processes.

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