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Curr Opin Chem Biol. 2002 Oct;6(5):659-65.

In vivo neurochemical monitoring by microdialysis and capillary separations.

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  • 1Department of Chemistry and Pharmacology, 930 North University, University of Michigan, Ann Arbor 48109-1055, USA.


Microdialysis is valuable for studying the neurochemical changes underlying behavior. Recent advances include the application of the high-sensitivity methods of capillary electrophoresis and capillary liquid chromatography with mass spectrometry to dialysate analysis. These methods have improved temporal resolution, spatial resolution, multi-analyte capability and potential for compound discovery.

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