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Curr Opin Immunol. 2002 Dec;14(6):705-8.

Complement in allergy and asthma.

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  • 1Department of Medicine, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.


The complement system is a vital link between innate and adaptive immunity. Recently, several investigators have implicated the complement anaphylatoxins C3a and C5a as potential effectors in Type 1 hypersensitivity reactions, including urticaria, rhinitis and asthma. Thus, complement activation may synergize with classical IgE mediated responses, and inhibition of complement may prove therapeutic.

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