Cannabidiol: an overview of some pharmacological a...[J Clin Pharmacol. 2002]

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1: J Clin Pharmacol. 2002 Nov;42(11 Suppl):11S-19S. Links

Cannabidiol: an overview of some pharmacological aspects.

Mechoulam R, Parker LA, Gallily R.

Deportment of Medicinal Chemistry and Natural Products, Hebrew University of Jerusalem, Israel.

Over the past few years, considerable attention has focused on cannabidiol (CBD), a major nonpsychotropic constituent of cannabis. The authors present a review on the chemistry of CBD and discuss the anticonvulsive, antianxiety, antipsychotic, antinausea, and antirheumatoid arthritic properties of CBD. CBD does not bind to the known cannabinoid receptors, and its mechanism of action is yet unknown. It is possible that, in part at least, its effects are due to its recently discovered inhibition of anandamide uptake and hydrolysis and to its antioxidative effect.

PMID: 12412831 [PubMed - indexed for MEDLINE]

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