Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Psychiatry. 2002 Nov;159(11):1929-32.

Frontal white matter microstructure and treatment response of late-life depression: a preliminary study.

Author information

  • 1Department of Psychiatry, Weill Medical Colege, Cornell University, and the Nathan Kline Institute, Orangeburg, NY 10605, USA. gsalexop@med.cornell.edu

Abstract

OBJECTIVE:

This study tested the hypothesis that microstructural abnormalities in white matter areas of the brain containing frontostriatal tracts are associated with a low rate of remission of geriatric depression.

METHOD:

Thirteen older patients with major depression received open, but controlled, treatment with citalopram at a target daily dose of 40 mg for 12 weeks. Diffusion tensor imaging was used to determine fractional anisotropy in preselected white matter regions.

RESULTS:

Survival analysis with Cox's proportional hazards model revealed that lower fractional anisotropy of the right and the left frontal white matter regions 15 mm above the anterior commissure-posterior commissure plane was associated with a low remission rate after age was considered. Remission was not significantly associated with fractional anisotropy of lower frontal regions or a temporal region.

CONCLUSIONS:

Microstructural white matter abnormalities lateral to the anterior cingulate may be associated with a low rate of remission of geriatric depression.

PMID:
12411231
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Write to the Help Desk