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Radiology. 2002 Nov;225(2):487-93.

Effect of transmyocardial laser revascularization on myocardial perfusion and left ventricular remodeling after myocardial infarction in rats.

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  • 1Physikalisches Institut (EP5), Universität Würzburg, Josef Schneider-Strasse 2, 97080 Würzburg, Germany.

Abstract

PURPOSE:

To monitor perfusion changes in remote myocardium caused by transmyocardial laser revascularization (TMLR) and to investigate the influence of TMLR on left ventricular morphology and function.

MATERIALS AND METHODS:

The coronary arteries were ligated in 32 Wistar rats. Eight weeks later, cine magnetic resonance (MR) imaging was performed in both the treatment (n = 12) and control group (n = 8). TMLR was then performed in the remote myocardium in the treated group. Twelve weeks after myocardial infarction, cine MR imaging, including dobutamine-induced (10 micro g per kilogram of body weight per minute via the tail vein) stress, was repeated and followed with hemodynamic measurements in both groups and with perfusion MR imaging (in-plane resolution, 140 x 140 micro m) of the isolated heart at rest and during nitroglycerin-induced stress in the TMLR group (n = 10).

RESULTS:

Left ventricular dilatation and hypertrophy were enhanced in the TMLR group (change in end-diastolic volume at 8-12 weeks: control group, 24.6 micro L +/- 16.7 and TMLR group, 81.7 micro L +/- 15.7; change in left ventricular mass: control group, 54.5 mg +/- 19.2 and TMLR group, 124.1 mg +/- 30.7; P <.03 for both). Ejection fractions at rest were approximately equal (control group, 40% +/- 2; TMLR group, 38% +/- 2; P value not significant), but during dobutamine-induced stress, the ejection fraction was higher in the TMLR group (54.4% +/- 4.9; control group, 47.4% +/- 4.8; P <.05). TMLR-treated areas were better perfused than was untreated myocardium (difference in perfusion: TMLR-treated vs control region, 3.89 mL/min/g +/- 0.83 at rest vs 2.29 mL/min/g +/- 1.06 during nitroglycerin-induced stress; P <.05 for both). Hemodynamic measurements revealed no differences between groups.

CONCLUSION:

High-spatial-resolution perfusion MR imaging depicted a significant perfusion improvement after TMLR. Post-myocardial infarction remodeling of the left ventricle was found to be enhanced.

Copyright RSNA, 2002

PMID:
12409584
[PubMed - indexed for MEDLINE]
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