Angew Chem Int Ed Engl. 2001 Dec 17;40(24):4688-4691.

The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-The Order of the Cyclization Steps This work was supported by the Deutsche Forschungsgemeinschaft (SFB 323) and by a grant of the EU (MEGATOP, QLK3-1999-00650). R. D. S. gratefully acknowledges the support of a Feodor-Lynen Fellowship granted by the Alexander-von-Humboldt Stiftung. We thank Corina Bihlmaier and Volker Pfeifer for help with transformation and Southern hybridization, J. A. Moss (La Jolla (USA)) for critical comments on the manuscript and Prof. Dr. M. E. Maier and Prof. Dr. H.-P. Fiedler (Tübingen) for generous support.

Bischoff D, Pelzer S, Bister B, Nicholson GJ, Stockert S, Schirle M, Wohlleben W, Jung G, Süssmuth RD.

Institut für Organische Chemie Universität Tübingen Auf der Morgenstelle 18, 72076 Tübingen (Germany).

PMID: 12404385 [PubMed - as supplied by publisher]

LinkOut - more resources

Full Text Sources:

Research Materials:

online strain list - StrainInfo

Libraries:

LinkOut Holdings

Supplemental Content

The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-New Insights into the Cyclization Steps This work was supported by the Deutsche Forschungsgemeinschaft (SFB 323). We thank M. Schierle, Dr. S. Stevanovic and Prof. H.-G. Rammensee for help with Edman degradation and J. Turner, Prof. B. List and Prof. D. Boger (La Jolla, USA) for discussions on the work.
Angew Chem Int Ed Engl. 2001 May 4; 40(9):1693-1696.

[Angew Chem Int Ed Engl. 2001]
A Rapid Total Synthesis of Spirotryprostatin B: Proof of Its Relative and Absolute Stereochemistry F.v.N. gratefully acknowledges the Alexander-von-Humboldt-Stiftung for a Feodor-Lynen fellowship that was kindly backed by Dr. R. Breslow as second host. This research was supported by the National Institutes of Health (Grant number HL 25848). We thank Dr. H. Osada (RIKEN) for providing us with spectra of the natural product. Furthermore we are grateful to Dr. D. Lichtblau from the Nakanishi laboratory for help with the CD spectra. We acknowledge the collaborative efforts of Ms. Maria Manzoni in these studies.
Angew Chem Int Ed Engl. 2000 Jun 16; 39(12):2175-2178.

[Angew Chem Int Ed Engl. 2000]
Structure and Dynamics of the Host-Guest Complex of a Molecular Tweezer: Coupling Synthesis, Solid-State NMR, and Quantum-Chemical Calculations S.P.B. thanks the Alexander von Humboldt Foundation for a research fellowship. C.O. acknowledges financial support by a Liebig "Habilitation" fellowship from the Fonds der Chemischen Industrie (FCI). This work was supported by the Deutsche Forschungsgemeinschaft (SFB 452) and the FCI. We thank Dr. Ingo Schnell for his involvement in the early part of this project, Dr. Kay Saalwächter for advice concerning the heteronuclear experiment, and Dr. Ulrich Burkert for his help during the synthesis of the complex.
Angew Chem Int Ed Engl. 2001 Feb 16; 40(4):717-720.

[Angew Chem Int Ed Engl. 2001]
ReviewTowards the classification of subpopulations of layer V pyramidal projection neurons.
Neurosci Res. 2006 Jun; 55(2):105-15. Epub 2006 Mar 15.

[Neurosci Res. 2006]
ReviewFunctional tissue engineering for ligament healing: potential of antisense gene therapy.
Ann Biomed Eng. 2004 Mar; 32(3):342-51.

[Ann Biomed Eng. 2004]
» See reviews... | » See all...

Cited by 5 PubMed Central articles

Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.
Belin P, Le Du MH, Fielding A, Lequin O, Jacquet M, Charbonnier JB, Lecoq A, Thai R, Courçon M, Masson C, et al. Proc Natl Acad Sci U S A. 2009 May 5; 106(18):7426-31. Epub 2009 Apr 22.

[Proc Natl Acad Sci U S A. 2009]
Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution.
Rausch C, Hoof I, Weber T, Wohlleben W, Huson DH. BMC Evol Biol. 2007 May 16; 7:78. Epub 2007 May 16.

[BMC Evol Biol. 2007]
ReviewChemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides.
Grünewald J, Marahiel MA. Microbiol Mol Biol Rev. 2006 Mar; 70(1):121-46.

[Microbiol Mol Biol Rev. 2006]
» See all...

Structures reported by this article

Crystal Structure Of Oxyb, A Cytochrome P450 Implicated In An Oxidative Phenol Coupling Reaction During Vancomycin Biosynthesis

PDB: 1LGF

Source: Amycolatopsis orientalis

Method: X-Ray Diffraction | Resolution: 2.2 Å
» See all 2 structures...

Patient drug information

Vancomycin (Vancocin®)
Vancomycin is used to treat colitis (inflammation of the intestine caused by certain bacteria) that may occur after antibiotic treatment. Vancomycin is in a class of medications called glycopeptide antibiotics. It works ...
Source: AHFS Consumer Medication Information

All links from this record

Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Related Articles
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Structure
Three-dimensional structure records in the NCBI Structure database for data reported in the current articles.
3D Domains
Structural domains in the NCBI Structure database that are parts of the 3D structures reported in the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-The Order of the Cyclization ...The Biosynthesis of Vancomycin-Type Glycopeptide Antibiotics-The Order of the Cyclization Steps This work was supported by the Deutsche Forschungsgemeinschaft (SFB 323) and by a grant of the EU (MEGATOP, QLK3-1999-00650). R. D. S. gratefully acknowledges the support of a Feodor-Lynen Fellowship granted by the Alexander-von-Humboldt Stiftung. We thank Corina Bihlmaier and Volker Pfeifer for help with transformation and Southern hybridization, J. A. Moss (La Jolla (USA)) for critical comments on the manuscript and Prof. Dr. M. E. Maier and Prof. Dr. H.-P. Fiedler (Tübingen) for generous support.
Electrochemical alternatives for drinking water disinfection.Electrochemical alternatives for drinking water disinfection.
Possible role of VEGF in the progression of kidney disease in streptozotocin (STZ)-induced...Possible role of VEGF in the progression of kidney disease in streptozotocin (STZ)-induced diabetic rats: effects of an ACE inhibitor and an angiotensin II receptor antagonist.
Towards safer, better healthcare: harnessing the natural properties of complex sociotechni...Towards safer, better healthcare: harnessing the natural properties of complex sociotechnical systems.
Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural d...Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization.

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

» See more...

PubMed

Display Settings:

Send to:

LinkOut - more resources

Full Text Sources:

Research Materials:

Libraries:

Supplemental Content

Related articles

Cited by 5 PubMed Central articles

Structures reported by this article

Patient drug information

All links from this record

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information