Viable but nonculturable Salmonella species recovery and systemic infection in morphine-treated mice

J Infect Dis. 2002 Nov 15;186(10):1526-9. doi: 10.1086/344353. Epub 2002 Oct 23.

Abstract

In vivo recovery and pathogenicity of Salmonella enterica serovar Oranienburg that became viable but nonculturable (VNC) in food were examined. VNC cells were completely eliminated in normal mice but caused systemic bacteremia and were subsequently lethal to morphine-treated mice. Therefore, morphine-treated mice might be a useful bioassay for VNC Salmonella species in implicated food items.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Female
  • Mice
  • Mice, Inbred BALB C
  • Morphine / pharmacology*
  • Salmonella Infections / microbiology*
  • Salmonella Infections / mortality
  • Salmonella enterica / drug effects
  • Salmonella enterica / pathogenicity*

Substances

  • Morphine