Nutr Rev. 2002 Oct;60(10 Pt 2):S15-9; discussion S68-84, 85-7.

The role of leptin in the control of body weight.

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Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Abstract

Physiologic responses to high and low leptin concentrations are strikingly asymmetrical. High concentrations often produce minimal effects, whereas low concentrations provoke strong counterregulatory responses. A model and rationale for the physiology is presented.

PMID:: 12403079; [PubMed - indexed for MEDLINE]

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