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Nat Rev Drug Discov. 2002 Aug;1(8):609-20.

Endogenous kynurenines as targets for drug discovery and development.

Author information

  • 1Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK. T.W.Stone@bio.gla.ac.uk

Abstract

The kynurenine pathway is the main pathway for tryptophan metabolism. It generates compounds that can modulate activity at glutamate receptors and possibly nicotinic receptors, in addition to some as-yet-unidentified sites. The pathway is in a unique position to regulate other aspects of the metabolism of tryptophan to neuroactive compounds, and also seems to be a key factor in the communication between the nervous and immune systems. It also has potentially important roles in the regulation of cell proliferation and tissue function in the periphery. As a result, the pathway presents a multitude of potential sites for drug discovery in neuroscience, oncology and visceral pathology.

PMID:
12402501
[PubMed - indexed for MEDLINE]
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