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Science. 2002 Oct 25;298(5594):789-91.

Alzheimer's disease is a synaptic failure.

Author information

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, and the Harvard Center for Neurodegeneration and Repair, Boston, MA 02115, USA. selkoe@cnd.bwh.harvard.edu

Abstract

In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid beta protein.

PMID:
12399581
[PubMed - indexed for MEDLINE]
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