- Erratum in:
- Science. 2003 Mar 14;299(5613):1663.
Corepressor-dependent silencing of chromosomal regions encoding neuronal genes.
Lunyak VV,
Burgess R,
Prefontaine GG,
Nelson C,
Sze SH,
Chenoweth J,
Schwartz P,
Pevzner PA,
Glass C,
Mandel G,
Rosenfeld MG.
Howard Hughes Medical Institute (HHMI), Department of Computer Science and Engineering, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, CA 92093-0648, USA.
The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex. Silencing of neuronal-specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST/NRSF response elements.
PMID: 12399542 [PubMed - indexed for MEDLINE]