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Cancer Cell. 2002 Oct;2(4):251-2.

MMP9 potentiates pulmonary metastasis formation.

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  • 1Cancer Research Institute, University of California, San Francisco 2340 Sutter Street, San Francisco, CA 94143, USA.


Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

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