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Psychopharmacol Bull. 2001 Summer;35(3):135-49.

Premenstrual exacerbations of mood disorders.

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  • 1Department of Psychiatry, East Tennessee State University, Quillen College of Medicine, Box 70567, Johnson City, TN 37614, USA. millerm@etsu.edu


Premenstrual exacerbation of mood disorders has received little attention, despite the recent interest in premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS). Differentiating between PMDD/PMS and other disorders, which worsen premenstrually, is a poorly understood diagnostic challenge. Controversy also focuses on a possible coexistence of PMDD and other mood disorders. This review discusses the differences between mood-disorder exacerbations and premenstrual disorders, evidence for premenstrual magnification of mood disorders, and possible mechanisms for these variations as well as clinical implications.

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