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Genet Med. 2002 Sep-Oct;4(5):336-45.

Genetic susceptibility to aminoglycoside ototoxicity: how many are at risk?

Author information

  • 1The Bobby R. Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030, USA.

Abstract

PURPOSE:

To assess the occurrence of two mutations associated with susceptibility to aminoglycoside ototoxicity.

METHODS:

Genetic analysis of anonymized, residual diagnostic specimens.

RESULTS:

One occurrence of the A1555G mutation and seven occurrences of the 961delT + C(n) nucleotide change were found. Two previously unreported sequence changes, T961G and 956-960insC, were also found in six and five specimens, respectively.

CONCLUSIONS:

Genetic susceptibility to aminoglycoside ototoxicity may be more common than previously suspected. Further study of the 961delT + C(n) mutation is recommended to confirm its role in aminoglycoside ototoxicity and assess penetrance and variability with and without exposure to aminoglycoside antibiotics.

PMID:
12394346
[PubMed - indexed for MEDLINE]
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