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    J Neurosci Res. 2002 Nov 1;70(3):357-60.

    Role of mitochondrial dysfunction in Alzheimer's disease.

    Castellani R, Hirai K, Aliev G, Drew KL, Nunomura A, Takeda A, Cash AD, Obrenovich ME, Perry G, Smith MA.

    Source

    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA. rjc8@po.cwru.edu

    Abstract

    Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease.

    Copyright 2002 Wiley-Liss, Inc.

    PMID:
    12391597
    [PubMed - indexed for MEDLINE]

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