Format

Send to:

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 2002 Oct 23;530(1-3):9-16.

New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer.

Author information

  • 1Institut de Chimie Pharmaceutique Albert Lespagnol, Faculté de Pharmacie, Laboratoire de Toxicologie, 3 Rue du Professeur Laguesse, P.O. Box 83, 59006 Lille Cedex, France. murielle.mimeault@ed.univ-lille1.fr

Abstract

Recent data on the cellular ceramide functions and its involvement in the apoptotic/necrotic cell death as well as its anticarcinogenic properties are presented. The emphasis is on the connections between the ceramide and caspase signaling pathways during the apoptotic cell death process. Notably, the experimental strategies and pharmacological tools used for establishment of the role of ceramide in triggering cell death are described. Moreover, the importance of a compartmentation of endogenous ceramide within the plasma membrane microdomains, lysosomes and mitochondria is discussed. Information on the deregulated functions of ceramide and caspase signaling pathways in several metastatic cancer types is also presented.

PMID:
12387858
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk