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Antimicrob Agents Chemother. 2002 Nov;46(11):3634-6.

In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies.

Author information

  • 1Department of Microbiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA.

Abstract

We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with > or =99% killing at physiological concentrations.

PMID:
12384379
[PubMed - indexed for MEDLINE]
PMCID:
PMC128738
Free PMC Article
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