Format

Send to:

Choose Destination
See comment in PubMed Commons below
Brain Res. 2002 Sep 6;948(1-2):138-44.

Impaired axonal transport of cortical neurons in Alzheimer's disease is associated with neuropathological changes.

Author information

  • 1The Netherlands Institute for Brain Research, Amsterdam, The Netherlands. j.dai@ioi.knaw.nl

Abstract

Using a novel in vitro post mortem tracing method, we demonstrate a decrease of axonal transport in the temporal cortex neurons as compared to axonal transport in the prefrontal cortex neurons in AD patients, but not in non-demented controls. The decrease of axonal transport is related to the degree of neuropathological changes, as the temporal cortex undergoes more severe neuropathological changes in AD. The present study provides, for the first time, direct evidence of the presence of impaired axonal transport in AD brains.

Copyright 2002 Elsevier Science B.V.

PMID:
12383965
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk