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Immunology. 2002 Oct;107(2):176-82.

CD20-mediated apoptosis: signalling through lipid rafts.

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  • 1Immunology Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1. jdeans@ucalgary.ca

Abstract

CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as lipid rafts, enriched in src-family tyrosine kinases and other signalling effectors, suggests an indirect mechanism of anti-CD20-induced apoptosis in which activation of src-family kinases occurs as a consequence of lipid raft clustering.

PMID:
12383196
[PubMed - indexed for MEDLINE]
PMCID:
PMC1782791
Free PMC Article
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