Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Semin Clin Neuropsychiatry. 2002 Oct;7(4):234-42.

Functional neuroimaging studies of the amygdala in depression.

Author information

  • 1Department of Psychiatry, W.M. Keck Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin, Madison, WI 53705, USA. pwhalen@facstaff.wis.edu

Abstract

Here we review human functional neuroimaging studies suggesting that the amygdala may play a key role in depression. We begin by reviewing animal and human data concerning the function of the amygdala. We then compare these results with those of neuroimaging studies of normal human amygdala function. Finally, we discuss functional neuroimaging studies of the amygdala in depression in light of the animal and human data. We conclude that the initial studies of this disorder provide evidence of amygdala involvement. Furthermore, we suggest that the scope of the amygdala's involvement may go beyond its well-known role in fear to its more subtle and generalized role in modulating moment-to-moment vigilance levels.

Copyright 2002, Elsevier Science (USA). All rights reserved.

PMID:
12382206
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk