Ann Genet. 2002 Jul-Sep;45(3):165-8.

TPA stimulation culture for improved detection of t(11;14)(q13;q32) in mantle cell lymphoma.

Barouk-Simonet E, Andrieux J, Copin MC, Grardel-Duflos N, Huyghe P, Patte JH, Preudhomme C, Quesnel B, Laï JL.

Source

Laboratoire de Génétique Médicale, Barre Nord Hôpital Jeanne de Flandre, CHRU de Lille, Lille, France.

Abstract

Cytogenetic analysis of mantle cell lymphoma (MCL), characterized by the presence of t(11;14)(q13;q32) translocation, is often difficult because of the low proliferating rate of MCL cells and the presence of normal cells in bone marrow which may interfere with growth of MCL cells. We describe herein a TPA (12-O-tetradecanoylphorbol 13-acetate) stimulated culture to improve detection of t(11;14)(q13;q32) in 20 MCL patients regardless of the samples used.

PMID:: 12381451; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Tetradecanoylphorbol Acetate

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12-O-TETRADECANOYLPHORBOL-13-ACETATE - HSDB

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